IJOH Vol.10 No. 2 (July-December) Article - 1
Review Article
International Journal of One Health, 10(2): 161-171
https://doi.org/10.14202/IJOH.2024.161-171
Antimicrobial resistance at the human–animal–environment interface: A focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions
2. Department of Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, UCSI University, Cheras 56000 Wilayah Persekutuan Kuala Lumpur, Malaysia.
3. Department of Community Medicine, International Medical School, Management and Science University, 40100 Shah Alam, Selangor, Malaysia.
4. Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
5. Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
6. Department of Farm and Exotic Animals Medicine and Surgery, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
7. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Cheras 56000 Wilayah Persekutuan Kuala Lumpur, Malaysia.
8. Department of Graduate Public Health, College of Veterinary Medicine, Tuskegee University, Tuskegee, AL 36088, United States.
Understanding and combating antimicrobial resistance (AMR) is increasingly centered on the intricate relationship between humans, animals, and the environment, with Escherichia coli being the main source of AMR-related fatalities worldwide. E. coli, though prevalent in the intestines of humans and warm-blooded creatures, demonstrates wide ecological adaptability in both intestinal and extraintestinal habitats. This study explores the dynamics, implications, and future directions of antimicrobial-resistant E. coli (AREC) transmission and clinical significance. We investigated the spread of antibiotic-resistant strains among humans, animals, and the environment, illuminating the impact of healthcare and agriculture practices, as well as environmental contamination. The implications of AREC infections are addressed, emphasizing the challenges in treatment due to limited antibiotic options, increased morbidity and mortality rates, and economic burdens on healthcare systems and agriculture, as well as the urgent need for a One Health approach to combat AMR through collaborative efforts across disciplines. Proposed future directions encompass enhanced surveillance, innovative antimicrobial stewardship, and alternative treatment modalities.
Keywords: antimicrobial stewardship, antimicrobial-resistant Escherichia coli, clinical implications, One Health, surveillance strategies, transmission dynamics.
How to cite this article: Fatokun O, Selvaraja M, Anuar H, Jamaludin TZMT, Ismail SNS, Mansor R, Shah SA, and Oranye N (2024) Antimicrobial resistance at the human–animal–environment interface: A focus on antimicrobial-resistant Escherichia coli transmission dynamics, clinical implications, and future directions, Int. J. One Health, 10(2): 161-171.
Received: 03-04-2024 Accepted: 24-06-2024 Published online: 25-07-2024
Corresponding author: E-mail:
DOI: 10.14202/IJOH.2024.161-171
Copyright: Fatokun, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
